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GHRP-6
and Hexarelin
By Anthony Roberts
Earlier this year, I was interviewed by a
major online bodybuilding
site (the interview was titled “Chemically
Insane”), and in that interview, I
predicted that various peptides would become the newest trend in
performance
enhancing drugs. For the most part, I was correct, and now
they’re very popular
and widely available, although still relatively new.
So, several months ago, I began my
experimentation with
various peptides, mostly with the goal of figuring out the best way to
use
them. My last major article examined my experiences with the two most
popular
peptides (IGF and MGF) currently on the market. This time around,
I’m going to
tell you about my experience with Hexarelin and GHRP-6, two lesser
known
peptides. With Lr3IGF-1, the use and goals of use is pretty
straightforward…you
pretty much use it to gain muscle and lose fat; on rare occasions,
people use
it to rehab an injury (I actually provided a full rehab protocol using
IGF-1 in
my first e-book). With MGF, it’s even simpler…you
use it to increase muscle
size, period.
Using the other peptides is a bit more
complicated, and
there are a couple of other reasons you might want to consider using
them…but
I’m getting a bit ahead of myself. The first thing I do when
I’m researching a
new anabolic is to jump on the internet and do some research in all of
the
available medical databases, and exhaust every search engine imaginable
with
keywords related to the new compound. The next thing I do is typically
to get a
couple of vials and try it for myself. I’m in a very unique
position with
regards to trying new compounds; in the case of several compounds
(Esterless
Boldenone, Masteron Enanthate, Stealth Injectables, etc…) I
was actually able
to try the products before they were released to the general public. In
the
case of Hexarelin and GHRP-6, I have had the opportunity to experiment
with
them for the past few months.
When I first received my vials of GHRP-6
and Hexarelin, I
did what most people probably do…I reconstituted them, shot
first, and asked
questions later. I thought it would be a great idea to fire up 600mcs
of GHRP-6
just before a heavy max effort deadlift session. Bad idea. I have a 45
minute
drive to my gym (I happen to workout at a military academy, where I
coach), and
halfway there, I started to get a bit hungry. No problem, right?
We’ve all
worked out a bit hungry…well, that’s what I
thought at first. Then when I hit
about 400lbs into my deadlifts, I started getting dizzy…I
broke into a cold
sweat, and I had to sit down. I rushed to get some simple carbs into my
body as
quickly as possible, thinking that I was going hypoglycemic.
Ok…I wasn’t going
hypoglycemic, but it was pretty bad. That workout was shot. Still, I
was
wondering if I could actually slip into some kind of severe
hypoglycemia from a
shot of GHRP-6…it certainly felt like I could.
So, naturally, I was interested, and did
some experimenting.
I waited a day and invited a friend over to my place…then I
did another shot of
600mcg (split bilaterally, 300mcg into each leg, as a subcutaneous
shot). Then
we sat around and waited, with a bunch of simple carbs ready. I got
hungry, I
was uncomfortable, and it wasn’t too much fun, but we sat
there for a good
couple of hours, and I didn’t pass out (in case
you’re wondering, the friend
was there to drive me to the hospital, in case I actually did pass
out). Ok…so
that settles that. Originally, I thought that maybe GHRP-6 operated by
inducing
some kind of mild hypoglycemia (hypoglycemia increases GH output). But
that’s
not how it actually works…
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Growth Hormone Releasing Peptide- 6
(GHRP-6) is a synthetic
hexapeptide which stimulates the release of Growth Hormone. It
accomplishes
this by two totally separate mechanisms. On the one hand, it amplifies
your
body’s natural Growth Hormone Releasing Hormone (GHRH) signal
transduction
pathway, and on the other hand, acts as a
functional antagonist of the
hormone which causes inhibition of GH secretion (somatostatin) (1-3).
GHRP-6
also has the benefit of being able to directly stimulate the anterior
pituitary gland, resulting in increased GH release. So although my
initial thoughts on the mechanism of action for this stuff was wrong, I
was enthused when my research revealed that GHRP-6 induced GH secretion
occurs by several mechanisms. Most importantly, those mechanisms are
the induction of GHRH release from the hypothalamus, stimulation
of GH release from somatotrophs, joint actions of GHRH and antagonism
of somatostatin, and finally by pronounced antagonism of somatostatin
action on somatotrophs (1-4). However, it bears clarification
that GHRP-6 is not dependant on the GHRH pathway…it can boost
your growth hormone levels without necessarily needing to elevate GHRH.
This is important because if that pathway has been inhibited by long
term GH use, GHRP-6 can still get your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system,
(4) which can provide added benefits in neuroprotection as well as
muscular strength increases for the user. Much of the strength
increases we see with Anabolic Steroids in the Dihydrotestosterone
family are suspected to be through a similar stimulation of the Central
Nervous System. In my experience with GHRP-6 use, strength levels
typically go up within the first week of starting out.
BUY RESEARCH GHRP-6
Increases in Growth Hormone levels in the body are typically
accompanied by strength increases, muscle hypertrophy (growth), and
lipolysis (fat loss). Other results experienced with increased GH
levels are recuperative effects on joints and injuries; connective
tissue strengthening and bone mineral density improvements are
commonplace. Enhanced GH secretion also leads to the liver secreting
more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the
primary anabolic mechanism of action for Growth Hormone. In the case of
GHRP-6, I gained quite a bit of weight when I was running it at the
600mcg/day level. I think that this was probably due to overfeeding
that almost always accompanied my shot contributed to this weight gain.
I gained about 12lbs in 2 weeks. I think that the same way people often
throw EQ into bulking cycles to increase appetite stimulation, I would
suggest using GHRP-6 instead. It’s not anywhere near as anabolic,
but the appetite increase is far above anything I’ve ever
experienced with any anabolics.
The women I know who have used GHRP-6 all had to discontinue its use
because it was making them gain weight too quickly. But then again,
most of the women who I know are national level (or professional)
physique competitors, and at most need an additional 5-10lbs of muscle
at most. GHRP-6 just put too much weight on them too quickly.
After experimenting with GHRP-6 for weight gain, I lowered the dose
substantially and used it to help rehab a knee injury that had been
bothering me for a couple of years. In this case, I lowered it to
100mcg/day, shot sub-q into the knee (ouch!). At this dose you
won’t find the extreme hunger that a high dose of it usually
causes, and a 5mg bottle of GHRP-6 is going to last for months, and
I’m confidant that it’s going to be enough to rehab
virtually any injury (in my case, I had done extensive damage to my
knee over the years, culminating in a traumatic injury playing on
turf…which resulted in my semi-retirement from competitive
athletics). Anyway, I combined GHRP-6 with a knee rehab protocol
designed by Eric Cressey, M.A. C.S.C.S., and advice from one of my
research assistants, who has a degree in Sports Medicine. Taken this
way, I used GHRP-6, and rehabbed my knee to almost where it was prior
to my beginning my career in athletics. If you have an injury, find
yourself a good rehab protocol, and try a low dose of GHRP-6. I bet
you’ll be surprised.
Oh…and this brings me to another point. I’m sure most
people subscribe to the theory that peptides only last for a couple of
weeks in their reconstituted form. Well, after I had my GHRP-6
reconstituted for well over a month, I tried a shot at my old 600mcg
dose, and guess what happened? Yeah, I got a huge increase in appetite
within the hour. This tells me that we’re really underestimating
the amount of time that a reconstituted peptide can retain its potency.
I’m betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the
inhibition of GH release, it has been used immediately following either
GH or IGF-1 cycles, to recover natural GH production by inhibiting
somatostatin action. It has also been used concurrently with those
compounds to negate some of the effects of those compounds on natural
GH production. Most people who use IGF never actually realize that as
IGF is part of the hormonal cascade that GH initiates, it is also part
of the Negative feedback loop for it.
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Typical doses of GHRP-6 range from 100mcg/day injected subcutaneously
(for connective tissue strengthening) to 500mcg/day (for an anabolic
effect). After experimentation with a wide variety of doses, and input
from several people who have also used the product, I think that
500mcg/day is the upper limit of effective dosing for GHRP-6.
The most rapid side effect experienced with GHRP-6 is extreme hunger,
which typically occurs within an hour of injection. This could be due
to a possible effect on blood sugar lowering, or more likely (I
suspect) due to its influence on Ghrelin (5), stimulated by the peptide
influenced release of GH. Ghrelin, by the way, increases appetite and
speeds gastric emptying. This means…even if you weren’t
hungry a second ago, and your Ghrelin levels go up too
much…you’ll be starving soon.
If I were looking to figure out the best way to use GHRP-6 in a bulking
cycle, I would simply take my favorite bulking cycle, and run GHRP-6
with it at a daily dose of 600mcg/day, shot post-workout. The reason
for the post-workout dosing is to take advantage of the appetite
stimulating properties, at the same time as taking maximum advantage of
the anabolic properties of the GH release that it will cause. And
I’d probably consider using some insulin as well, because insulin
is highly anabolic on its own, but also because the GH response to
GHRP-6 is elevated with concurrent use of insulin (6). Again, this is
only how I’d do it personally, and I’m sure people will
experiment with things and find the optimal way to get the results they
want on an individual basis. GHRP-6 and this is no exaggeration, will
put as much weight on you as nearly any steroid. If you’re not
careful, you’ll gain too much fat…my recommendation is to
use this stuff on your off season bulking cycles.
Overall, I was pretty impressed with GHRP-6, in my experience with it.
Its ability to put weight on me was actually too potent, although the
strength gains were nice. Now, I’ll mostly use GHRP-6 for post
cycle therapy from IGF use, or when I need to get rid of an injury.
I’ve never used Growth Hormone (let’s face
it…it’s expensive, and Lr3IGF-1 + MGF is a much better
buy), but when I used Hexarelin, I experienced most of the results that
GH users report, but in much less time. Out of the two GH
secretagogues that I tried (Hexarelin and GHRP-6), Hexarelin is
definitely my favorite. In my own personal case, I’m 28 years old
right now, and not looking to add any more mass. I can comfortably
maintain my bodyweight with my doctor-prescribed anabolics (I’m
on permanent Hormone Replacement Therapy), and now I mostly focus on
athletic-oriented goals. So strength gains without much weight, and
maybe a bit of bodyfat loss, are my primary concerns. If I were in my
early 20’s and still looking to gain weight, I’d probably
be in love with GHRP-6, but for this stage of the game, I prefer the
effects I’ve found with Hexarelin.
Hexarelin is a GH secretagogue, specifically a hexapeptide which
stimulates the release of growth hormone (GH) in both GH deficient as
well as normal humans. When given by injection, plasma growth hormone
concentrations increased (with a dose-dependent response curve). Growth
Hormone levels peak at the half-hour mark after injection, then
decreasing to baseline values within roughly four hours (half-life is
about 55 minutes). (7)
Of course, as we know
from other peptides like GHRP-6, this type of surge in Growth Hormone
levels has been positively correlated with increases in strength,
muscle hypertrophy, and fat loss. Therefore, the many advantages of
having GH secreted in larger amounts via administration of Hexarelin
are comparable to the effects of injectable growth hormone
administration. In my own case, I found that Hexarelin increased my
strength and even aided with fat-loss a bit, but didn’t put much
weight on me at all. This makes it very different from GHRP-6, which
piles tons of weight on me.
BUY RESEARCH GHRP-6
Although my knee injury was, for the most part, totally healed from my
use o GHRP-6, I suspect that Hexarelin would have produced very similar
results or that purpose. That’s because, as we already know,
increasing GH levels elicits a favorable increase in bone mineral
density. When I used Hexarelin, however, I was mostly interested in the
increase in GH which would provide me with both increased mitosis and
meiosis (each of which leads to hypertrophy, i.e. increased muscle
size), triglyceride hydrolysis which helps aid in fat loss. And since
there are GH receptors (though no IGF-1 receptors) in adipose tissue, I
decided to use my Hexarelin subcutaneously in my abdomen. Even though
the GH response is systemic (whole-body), it couldn’t hurt to
concentrate the shots where fat is more highly concentrated (which in
males is the abdomen). I used 200mcg/day of Hexarelin, shot sub-q (in
my case, being under 100kgs, this is just slightly over the maximum
response dose...as I later found out).
Hexarelin enhanced GH
secretion also leads to the liver secreting more IGF-1 (Insulin-Like
Growth Factor 1). IGF-1 is thought to be the primary causative factor
in the anabolic effects of Growth Hormone. It needs to be noted at this
point that data on this is actually conflicting, and I’ve seen
studies where (somehow?) Hexarelin elicits a release in GH without a
commensurate increase in IGF-1 levels. In my own experience with
Hexarelin, I found it to be reasonably anabolic on its own, and think
that the
But lets be realistic here; it’s important to realize that
Hexarelin is not going to produce results similar to high dose GH
cycles, in the normal person. This is because Hexarelin only stimulates
the increase of GH, and has been found to be effective up to 2mg/kg,
but after that dose does not really produce more results in terms of GH
secretion (7). Thus, a dose of 2mgs/kg is the upper limit for Hexarelin
use, while GH users in the professional ranks of athletics and
bodybuilding have gone as high as 10iu/day. Hexarelin, at 2mg/kg of
bodyweight has been compared by most users to the type of results seen
with 1-2iu/day of GH. At the price, though, Hexarelin is a much better
alternative. If you need the type of results that 3iu+/day of GH are
going to give you, then that’s an impossibility with Hexarelin
use. Still, for the price and for the effects, this stuff is a steal
when compared with using 2iu of GH every day.
One of my powerlifter
friends (read: Lab Rats), who assists me in some of my research used
Hexarelin while training for a meet. He had the dual purpose of
rehabbing a shoulder as well as trying to increase his bench press. As
you probably could have guessed, his bench went up, and his shoulder
seemed to have healed. He was using roughly half the dose of Hexarelin
I recommend for hypertrophy and fat loss, which worked out to about
50mcg/day shot 2x a day in the injured shoulder. His shoulder healed up
nicely, and his strength went up a bit. Neither myself nor my friend
had any increased appetite on Hexarelin, and I suspect that this is
because it has a much less profound effect on Ghrelin levels. The
strength gains we both received from its use were very similar to those
experienced with GHRP-6, but with very little weight gain, and
negligible fat loss. Hexarelin is a nice addition to a cutting cycle,
to make maximum use of the GH response to both anabolic steroids as
well as the GH induced response from training. And, it never hurts to
include something that’s going to help your joints on a cutting
cycle, since we know that the typical compounds used in a cutting cycle
(Winstrol, etc…) often cause joint problems. We can use the
added GH from the Hexarelin to help protect our otherwise compromised
joints on a cycle, without spending tons of money on GH.
BUY RESEARCH GHRP-6
Unlike GH, however, some
attenuation to Hexarelin occurs by week 4, and continues on up to 16
weeks of use. By separating Hexarelin cycles by 4 week off periods,
this attenuation can be totally reset, (9) and the next cycle of
Hexarelin will produce the same level of results as the first cycle.
During a cutting cycle, I recommend using Hexarelin for the weeks where
compounds such as Winstrol are used, and continuing its use for the
duration of the cycle. If you’re using Lr3IGF-1 on your cutting
cycle, then I recommend saving the Hexarelin for after the IGF use is
over.
Although, many athletes
use Hexarelin alone, others have used it after a Growth Hormone or
Insulin-Like Growth Factor one cycle, to as a form of Post-Cycle
Therapy for the recovery of their own natural GH and IGF-1 production.
Again, for this purpose, 2mg/kg, injected subcutaneously is the proper
dose per day.
Although they’re
new, and haven’t been experimented with too extensively in the
bodybuilding community, I think that both GHRP-6 and Hexarelin will be
used more commonly in the coming months and years. It took me far too
long to jump on the bandwagon with IGF, and I was far too slow to begin
my personal experimentation with MGF, so when these two peptides became
available to me, I didn’t want to let the opportunity go for too
long. Now, after some pretty extensive personal experimentation with
these two peptides, I think that Hexarelin is a great anabolic addition
to a cutting cycle, and GHRP-6 is probably the most potent
(non-steroid) weight gainer that I’ve ever used. Considering the
price, legal status, and availability, these two are probably going to
find their way into quite a few cycles over the next few years.
References:
1. Cheng K, Chan WW-S, Butler BS, Barreto A, Smith RG
1989 The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on GRF
stimulated growth hormone release and intracellular cAMP accumulation
in rat primary pituitary cell cultures. Endocrinology
124:2791–2797
2. Smith RG, Pong S-S, Hickey GJ, Jacks TM, Cheng K,
Leonard RJ, Cohen CJ, Arena JP, Chang CH, Drisko JE, Wyvratt Jr MJ,
Fisher MH, Nargund RP, Patchett AA 1996 Modulation of pulsatile GH
release through a novel receptor in hypothalamus and pituitary gland.
Recent Prog Horm Res 51:261–286
3. Leonard RJ, Chaung L-YP, Pong S-S 1991 Ionic
conductances of identified rat somatotroph cells studies by perforated
patch recording are modulated by growth hormone secretagogues. Biophys
J 59:254
4. Smith, Development of Growth Hormone Secretaogues, Endocrine Reviews, 26(3) 346-360
5. Ghrelin: structure and function. Physiol Rev. 2005 Apr;85(2):495-522. Review.
6. Penlava, A, et. al. Effect of growth hormone
(GH)-releasing hormone (GHRH), atropine, pyridostigmine, or
hypoglycemia on GHRP-6-induced GH secretion in man.J Clin Endocrinol
Metab. 1993 Jan;76(1):168-71.
7. Imbimbo, B.P., et. al Growth hormone-releasing
activity of hexarelin in humans. A dose-response study.Eur J Clin
Pharmacol. 1994;46(5):421-5.
PMID: 7957536 [PubMed - indexed for MEDLINE]
8. Kinetics and Disposition of Hexarelin, A Peptidic Growth Hormone Secretagogue, in Rats
Marie Roumi, Sylvie Marleau, Patrick du Souich, Tony Maggi, Romano Deghenghi, and Huy Ong
Drug Metab. Dispos., Jan 2000; 28: 44.
9. Rahim, A., Shalet, SM Does desensitization to hexarelin occur?
Growth Horm IGF Res. 1998 Apr;8 Suppl B:141-3.
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